Successful control of human onchocerciasis by mass-distribution of ivermectin (APOC) depends largely of two factors: The implication of additional control measures – i.e. strategies to reduce man-fly-parasite contact in the field, which we aim to assess quantitatively – and the speed of development of resistance against ivermectin, i.e. from yet unknown characteristics of the population biology of Onchocerca worms: mating behaviour, microfilarial production and turnover, which we propose to study in the bovine O. ochengi model. Premunition by cross-transmission of animal filariae, zooprophylaxis and ivermectin-facilitated immunity additionally influence the epidemiology of O. volvulus, but their beneficial effects vary according to local micro-epidemiological conditions
The program has research facilities on its own compound, including a house with kitchen facilities, a large parlour, a small office and two bedrooms, each with its own bathroom for resident scientists.
There are three store rooms which provide ample space for lab equipment, cattle food et.c. The supply of water and electricity is reliable.
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